Phosphatidic Acid as a Calcium I O N O P H O R E in Large Vesicle Systems
نویسندگان
چکیده
The ionophoretic capabilities of dioleoylphosphatidic acid (DOPA) for transporting calcium across phospholipid bilayers have been investigated. Calcium uptake by large unilamellar vesicles is shown to depend on the presence of DOPA. This uptake is sensitive to the nature and concentration of calcium chelators in the vesicle interior, indicating that accumulation results from DOPA-mediated translocation of calcium across the membrane. Further, it is shown that characteristics of DOPA-mediated Ca 2+ uptake are similar to those observed for the fungal calcium ionophore, A23187.
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